Interleukin-17A enhances osteogenic differentiation by activating ERK/MAPK in stem cells derived from human exfoliated deciduous teeth

Introduction: Human exfoliated deciduous teeth–derived stem cells (SHEDs) have been shown as an excellent source of bone regeneration. Interleukin-17A (IL-17A) facilitates differentiation in various cell types, including SHEDs. In this study, we demonstrated IL-17A’s stimulating effect on SHEDs osteogenic and further evaluated the role ERK/MAPK signaling pathway process. Methods: The function IL-17A differentiation, proliferative activity, MAPK cascade activation were investigated. Results: significantly enhanced alkaline phosphatase activities Furthermore, expression levels different proteins COL1A1, ALP, OPN, RUNX, OCN elevated IL-17A-treated Moreover, triggered SHEDs, evidenced by significant upregulation both downstream ERK targets, P38 JNK pathways, upstream activators. addition, time-dependently established participation SHED differentiation. Conclusion: These findings suggest that IL-17A-induced is necessary for to differentiate into osteoblasts. This reiterates significance particular intracellular controlling which a promising tissue